R.K. Srivastava, director general of the Directorate General of Health Services (DGHS), said one death each was reported from Bangalore, Nashik and Pune.
At least 123 people tested positive for the Influenza A (H1N1) virus Thursday, taking the total number affected with the contagious disease to 3,396, he added.
"We decided to do a limited analysis of death cases. So we collected case sheets of 30 random victims from seven affected states and did a medical analysis on them. The prime reason for death is people are coming late for treatment. The study has reasserted it," Srivastava told reporters.
He said the study also showed that most of those who died were in the age group of 14 to 44 years. "Most of these deaths are in the young productive age."
"Most of the people who have died came late to the hospitals and died on the fifth day of treatment. The most common symptoms were excessive cough and breathlessness," he added.
Srivastava said in most of the deaths, the infection had spread widely in the chest and H1N1 pneumonitis had kicked in.
Swine flu cases are bracketed in three categories - those who had mild flu-like symptoms, those with high fever, and those with chest congestion and other flu-like symptoms.
"Most deaths are of those who fall in the last category," Srivastava added.
He said those falling in the second and third categories should immediately go to the identified health facility, while those in the first category could go to a private hospital.
"The best way is to report it early so there is better redressal and treatment chance," he added.
However, he clarified that the study was in its nascent stage.
"Analysis will have to be compared with other positive cases before ascertaining a clear trend because the sample size is still small," Srivastava added.
He said the emphasis was earlier on providing testing facilities, but now it is focused on capacity building, diagnosis and treatment.
When asked whether the union health ministry was satisfied with the state government's work, he said: "Health is a state subject."
However, he said that if the health ministry was happy with the state-level capacity building to deal with swine flu spread, then there would have been no meeting with the state authorities.
"The centre's job is not just to show dissatisfaction but provide coordination and interventions when needed," he added.
Srivastava said they are also examining the clinical behaviour of the virus. Initial findings have shown that while earlier the disease was mild and the person would recover soon, now its behaviour has changed.
"The disease is more likely to stay and worsen. The disease came four months ago and it is no longer novel anymore, so states should make efforts and focus on building capacity and infrastructure for treatment," he added.
Shiv Lal, the director of National Centre for Disease Control (NCDC), which was earlier known as National Institute of Communicable Diseases (NICD), said: "About 16 private labs will be assisting in the testing of the H1N1 and we have identified more government centres."
These new testing centres are - Defence Research and Development Establishment (DRDO), Gwalior, Rajiv Gandhi Center for Biotechnology, Thiruvananthapuram and National Institute of Immunology in New Delhi.
He said in the meeting between union Health Minister Ghualam Nabi Azad and the state health ministers Aug 21, it was found that the northeast states do not have adequate infrastructure to tackle the problem.
"So we have sent six ventilators to northeastern states - two each for Arunachal Pradesh, Mizoram and Nagaland," he added.
He said since the seven northeastern states have no testing centres, they have asked the state public health authorities to coordinate with the Kolkata and Pune NCDC centres.
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